In regard to and with regard to are phrases that mean "regarding," "concerning," "on the subject of."
As regards—note the s on the end—means the same thing. Perhaps this is why people mindlessly pluralize regard and say in regards to and its partner in crime, with regards to.
Both of the following examples are correct: With regard to your friend, let's hope she is well. Compare that to With regards to your friend. Let's hope she is well.
In the first sentence, With regard to means "concerning." But in the second sentence, regards with an s is a plural noun meaning "best wishes."